Cronobacter sakazakii Pathogenesis of Necrotizing Enterocolitis by for Intestinal Epithelial Damage in the Recruitment of Dendritic Cells Is Responsible
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Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis.
Necrotizing enterocolitis (NEC) is an inflammatory intestinal disorder that affects 2%-5% of all premature infants. Enterobacter sakazakii, a common contaminant of milk-based powdered infant formula, has been implicated as a causative agent of sepsis, meningitis, and NEC in newborn infants, with high mortality rates. However, the role played by E. sakazakii in the pathogenesis of NEC is, to dat...
متن کاملLactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Cronobacter 1 ( Enterobacter ) sakazakii - induced nitric oxide both in vitro and in the newborn rat model of 2 necrotizing enterocolitis . 3
Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Cronobacter 1 (Enterobacter) sakazakii-induced nitric oxide both in vitro and in the newborn rat model of 2 necrotizing enterocolitis. 3 Catherine J. Hunter 1 , Monica Williams 1 , Mikael Petrosyan 1 , Yigit Guner 1 , Rahul Mittal 2 , Dennis 4 Mock 3 , Jeffrey S. Upperman 1, 4 , Henri R. Ford 1, 4 and Nemani V. Prasad...
متن کاملConditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice.
Necrotizing enterocolitis (NEC) is associated with a high morbidity and mortality in very low birth weight infants. Several hypotheses regarding the pathogenesis of NEC have been proposed but to date no effective treatment is available. Previous studies suggest that probiotic supplementation is protective. We recently reported that probiotic (Bifidobacterium infantis) conditioned medium (PCM) h...
متن کاملProbiotic Lactobacillus Species Strengthen Intestinal Barrier Function and Tight Junction Integrity in Experimental Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a serious intestinal disease that occurs in newborn infants. It is associated with major morbidity and affects 5% of all infants admitted to neonatal intensive care units. Probiotics have variable efficacy in preventing necrotizing enterocolitis. Tight junctions (TJ) are protein complexes that maintain epithelial barrier integrity. We hypothesized that the pro...
متن کاملInhibition of Cronobacter sakazakii Virulence Factors by Citral
Cronobacter sakazakii is a foodborne pathogen associated with fatal forms of necrotizing enterocolitis, meningitis and sepsis in neonates and infants. The aim of this study was to determine whether citral, a major component of lemongrass oil, could suppress putative virulence factors of C. sakazakii that contribute to infection. Sub-inhibitory concentrations of citral significantly decreased mo...
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تاریخ انتشار 2011